is best known for her role as ‘Karen Walker’ on NBC’s hit sitcom WILL & GRACE, for which she was awarded two Emmys, four Screen Actors Guild awards and five Golden Globe nominations.
The Los Angeles-born, Oklahoma-raised actress briefly enrolled as a Theatre major at Northwestern University before switching to English Literature. She starred in several campus plays and musicals nonetheless, gaining enough attention to allow her to successfully pursue professional theatre work in Chicago for six years, before moving to Los Angeles in 1985.
In Los Angeles, Megan soon won a lead role in the short-lived TV series, THE ELLEN BURSTYN SHOW, alongside Ellen Burstyn and Elaine Stritch. Several TV guest roles followed (SEINFELD, FRASIER, WINGS, MAD ABOUT YOU, CAROLINE IN THE CITY, CHINA BEACH, MURDER SHE WROTE), and a couple of series (MY LIFE AND TIMES, RACHEL GUNN, R.N).
In the mid-90's, Megan appeared in two Broadway musicals: a 1994 revival of GREASE, with Rosie O'Donnell, and 1995’s HOW TO SUCCEED IN BUSINESS WITHOUT REALLY TRYING, starring opposite Matthew Broderick. She returned to the Broadway stage in the Mel Brooks original musical, YOUNG FRANKENSTEIN, with Roger Bart and Sutton Foster. She also starred in the New Group's production of Sharr White's ANNAPURNA, opposite her husband, Nick Offerman-- this followed a successful run at L.A.'s Odyssey Theatre, where in 2009 Mullally also performed the role of Beverly Wilkins in Adam Bock's play THE RECEPTIONIST, for which she was awarded a Backstage West Garland Award. In 2014, Megan returned to Broadway for Terence McNally’s IT'S ONLY A PLAY alongside Nathan Lane, Matthew Broderick, F. Murray Abraham, Stockard Channing, Rupert Grint and Micah Stock. That same year, she performed the role of “Adelaide” in GUYS AND DOLLS opposite Nathan Lane at Carnegie Hall. The show resulted in rave reviews.
Most recently, Mullally can be seen opposite James Franco and Bryan Cranston in John Hamburg’s WHY HIM? The film was released by Fox on December 23rd. She also recently wrapped production for James Franco’s THE MASTERPIECE along with the Bob Byington directed comedy INFINITY BABY alongside husband Nick Offerman.
Previously, Mullally starred as “Leanne” in Sky TV’s YOU, ME AND THE APOCALYPSE which aired on NBC following a run in the UK. She starred in the show alongside Rob Lowe and Jenna Fischer and received favorable reviews from many critics. She also co-stared as Chief in Rob Corddry’s satirical double Emmy Award-winning TV series, CHILDREN'S HOSPITAL and recurred on PARKS AND RECREATION, as the evil Tammy, opposite her real-life husband, Nick Offerman. Mullally and Offerman recently guest starred together in a Season 2 episode of CBS’s LIFE IN PIECES. Mullally also recurs on Fox’s animated hit BOB'S BURGERS, has appeared as Lydia on the acclaimed cult hit show PARTY DOWN, and guested on 30 ROCK, WEB THERAPY, TROPHY WIFE, UP ALL NIGHT, and HAPPY ENDINGS.
On the big screen, she has been seen in A;EXANDER AND THE TERRIBLE, HORRIBLE, GOOD, VERY BAD DAY, SMASHED, KINGS OF SUMMER, ERNEST AND CELESTINE, DATE AND SWITCH, SOMEBODY UP THERE LIKES ME, and GBF. She also voiced the character Grandma Linda in HOTEL TRANSYLVANIA 2.
Last year, Mullally and Offerman toured their comedy show “Summer of 69: No Apostrophe” which will be recorded for a comedy special this year.
Mullally is in the band Nancy and Beth. Their first record will be released April 7, 2017. The band can be found on Twitter @nancyandbeth.